Konferencja Naukowa Studentów » 2004 » Biochemia i biofizyka
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Application of biophysical techniques in field of petide interactions with lipid membranes antimicrobial peptides cd.

Czwartek, 19 marca

3. CONCLUSIONS

Investigation of antimicrobial peptide mode of action on model lipid membranes by means of modern biophysical methods enables the good insight both in a macro and microscopic level of biological interactions. Combined approach of calorimetric and spectroscopic measurements results in a complex picture of changes both in peptide structure and the organization and properties of model membranes.

Autorzy: Tomasz Borowik, Per Eugen Kristiansen, Gerhard Gröbner

REFERENCES

[1] HANCOOK R. E. W., CHAPPLE D. S., Peptide antibiotics, Antimicrob. Agents Chemother. 43 (1999) 1317-1323
[2] BOMAN H. G., Peptide antibiotics and their role in innate immunity, Annu. Rev. Immunol. 13 (1995) 61-92
[3] EPAND M. E. et al. Mechanisms for the modulation of membrane bilayers properties by amphipathic helical peptides, Biopolymers 37 (1995) 319-338
[4] HANCOOK R. E. W., SCOTT M. G. The role of antimicrobial peptides in animal defences, Proc. Nat. Acad. Sci. USA 97 (2000) 8856-8861
[5] BOKVIST M., LINDSTRÖM F., WATTS A., GRÖBNER G., Two types of Alzheimer’s -Amyloid (1-40) peptide membrane interactions: aggregation preventing transmembrane anchoring versus accelerated surface fibril formation, J. Mol. Biol. 335 (2004) 1039-1049
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